PRODUCTS IN ORAL APPLICATIONS

Oral Applications

In oral applications phospholipids aim to enhance oral uptake and bioavailability of poorly water-soluble drug substances. They can reduce irritation of the stomach or help to protect the API from degradation.

The phospholipids are mainly applied in emulsions, dispersions, mixed micelles, (pro) liposomes, solid dispersions, and non-aqueous phospholipid formulations. They can serve as wetting agents, emulsifiers, solubilizers, or lipid matrix forming excipients. Such formulations can be converted into dry forms such as granules, powders, and tablets by adding appropriate excipients or directly filled, e.g., into capsules, sachets, or bottles.

Liquid Phospholipid Formulations
Liquid, non-aqueous concentrates of phospholipids in combination with oils or a water-miscible solvent like propylene glycol are suitable for dissolving APIs. Diluted in water, they help to disperse the API in the aqueous phase. They  may be directly filled into capsules, bottles, or sachets as dosage form.

Emulsions
When the drug has sufficient solubility in oils, O/W emulsions or self-emulsifying systems can be prepared with phospholipids as emulsifiers or co-emulsifiers.

(Mixed) Micelles
(Mixed) Micelles comprising phospholipids and bile salts mimic natural gut solubilization systems and are valued solubilizers, even for pediatric use.

Solid Dispersions
A poorly soluble API and a phospholipid, for example, spray-dried with or without polymers, form solid dispersions with the amorphous state of the drug. Upon hydration, the phospholipids act as wetting agents and solubilizers.

Phospholipids as API’s
Polyunsaturated/Polyenyl Phospholipids (PPL) derived from soybean are used for the prevention and treatment of liver diseases. These phospholipids suppress the formation of detrimental Radical Oxygen Species (ROS). They are available either as soybean phospholipid raw material or as formulated liquid products.

The products shown below represent a selection of our extensive product range.

Products

Soybean
LIPOID S 45 Lecithin fraction with 45 % phosphatidylcholine CAS-No. 8030-76-0
LIPOID S 75 Phospholipids with 70 % phosphatidylcholine CAS-No. 8030-76-0
LIPOID S 80 PPL Phospholipids with 73 – 79 % phosphatidylcholine CAS-No. 8030-76-0
SOLUTHIN® S 80 M Phosphatidylcholine with magnesium chloride (powdered compound), phosphatidylcholine content ≥ 64.0 % CAS-No. 8030-76-0
PHOSPHOLIPON® 90 G Phosphatidylcholine, content ≥ 94.0 %, granulated CAS-No. 97281-47-5
PHOSPHOLIPON® 80 H Phospholipids, hydrogenated, with 70 % phosphatidylcholine CAS-No. 92128-87-5
PHOSPHOLIPON® 90 H Phosphatidylcholine, hydrogenated, content ≥ 90.0 % CAS-No. 97281-48-6
LIPOID PPL-400 Waxy formulations of PPL phospholipids in hard-fat and soybean oil, phosphatidylcholine content ≥ 53.0 % CAS-No. 8030-76-0
LIPOID PPL-600 Fluid formulation of PPL phospholipids in medium-chain triglycerides, phosphatidylcholine content ≥ 37.0 % CAS-No. 8030-76-0
PHOSAL® MCT 30 % LIPOID S 75 (USP-NF) in medium-chain trigylcerides (USP-NF)
PHOSAL® 50 PG Phosphatidylcholine in propylene glycol, content ≥ 50.0 %
PHOSAL® 50 SA+ Phospholipid formulation of phosphatidylcholine, content ≥ 50.0 % in safflower seed oil
PHOSAL® 53 MCT Phosphatidylcholine in medium-chain triglyceride, content ≥ 53.0 %
PHOSAL® 75 SA Phosphatidylcholine in ethanol and safflower oil, content ≥ 72.0 %
LIPOID GPC sn-Glycero-3-phosphocholine, content ≥ 98.0 % CAS-No. 28319-77-9
LIPOID GPC 50 Mix Powder with 50 % sn-glycero-3-phosphocholine (GPC) from soybean CAS-No. 28319-77-9
LIPOID GPC 85 F Fluid concentrate of sn-Glycero-3-phosphocholine (≥ 98.0 %) in water CAS-No. 28319-77-9
Non-GMO Soybean
LIPOID P 45 Lecithin fraction with 45 % phosphatidylcholine CAS-No. 8030-76-0
LIPOID P 75 Phospholipids with 70 % phosphatidylcholine CAS-No. 8030-76-0
LIPOID P 100 Phosphatidylcholine, content ≥ 90.0 % CAS-No. 97281-47-5
LIPOID P LPC 80 Lysophosphatidylcholine, content 80 % and ≤ 20 % phosphatidylcholine CAS-No. 9008-30-4
LIPOID P 75-3 Phospholipids, hydrogenated, with 70 % phosphatidylcholine CAS-No. 92128-87-5
LIPOID P 100-3 Phosphatidylcholine, hydrogenated, content ≥ 90.0 % CAS-No. 97281-48-6
Sunflower (Non-GMO)
LIPOID H 90 Phosphatidylcholine, content ≥ 90.0 % CAS-No. 97281-49-7
LIPOID H 100 Phosphatidylcholine, content ≥ 94.0 % CAS-No. 97281-49-7
LIPOID H 100-3 Phosphatidylcholine from sunflower, hydrogenated, content ≥ 90.0 % CAS-No. 92128-87-5
PHOSAL® H 50 Phosphatidylcholine in sunflower oil, content ≥ 50.0 %
LIPOID H GPC sn-Glycero-3-phosphocholine, content ≥ 98.0 % CAS-No. 28319-77-9